Prevalence of chronic kidney disease (CKD) stages 3–5 is low among adolescents aged 12–17 years compared to adults, remaining below 1% across all NHANES cycles.
CKiD U25 equation used to estimate eGFR in adolescents. Data are not adjusted.
NHANES is a nationally representative, cross-sectional survey that is currently conducted every two years (since 1999) by CDC's National Center for Health Statistics among noninstitutionalized US civilian residents. The survey consists of a standardized in-home interview and a physical examination with blood and urine collected at a mobile examination center. Data were examined by combining two NHANES cycles to represent four-year periods from 2001 to 2016 and the 2017–March 2020 pre-pandemic cycle.
Note: Not all NHANES variables are collected for all years; therefore, some NHANES indicators may not utilize the full 20-year span.
Prevalence of CKD among adolescents based on eGFR <60 ml/min/1.73m2.
National Health and Nutrition Examination Survey (NHANES).
Noninstitutionalized U.S. adolescents aged 12–17 years.
2001–March 2020.
Adolescents aged 12–17 years with eGFR <60 ml/min/1.73m2.
Adolescents aged 12–17 years with serum creatinine measurements.
CKD is defined by estimated glomerular filtration rate (eGFR) <60 ml/min/1.73m2.
Based on CKiD U25 equation: k*(height [cm]/serum creatinine) If male: if age is less than 12 then k=39*(1.008**[age_years-12]) if age is 12–17 then k=39*(1.045**(age_years-12)) if age is 18–25 then k=50.8 If female: if age is less than 12 then k=36.1*(1.008**(age_years-12)) if age is 12–17 then k=36.1*(1.023**(age_years-12)) if age is 18–25 then k=41.4
Serum creatinine values used for eGFR calculation are standardized against isotope dilution mass spectrometry (IDMS).
Measured as part of the medical examination.
Kidney function is assessed from one-time cross-sectional measurement of serum creatinine.
Appropriate NHANES survey weights are used for all analyses; if relative standard error is greater than 30%, the estimates are not shown. Serum creatinine measurements are assay corrected for NHANES years 2005 and 2006 and prior to be combined with later years.