Odds of a family history of ESRD was 3-4x higher in adults with measured eGFR of 20-29 or 10-19 ml/min/1.73m² as compared to adults with an eGFR > 60 ml/min/1.73m².
Individuals of black race, females, the obese and those with diabetes or increased serum C-reactive protein (CRP; a measure of inflammation) concentrations were significantly more likely to report a family history of ESRD.
Chart Explanation: Adults within the lowest eGFR categories were significantly more likely to report a family history of ESRD. Multivariable analyses indicated that individuals of black race, females, the obese, and those with diabetes or increased serum C-reactive protein (CRP; a measure of inflammation) concentrations were significantly more likely to report a family history of ESRD.
Renal REGARDS represents a subcohort of 12,030 participants from the Reasons for Geographical and Racial Difference in Stroke (REGARDS) cohort study who. Participants are a population-based sample of adults, 45 years and older, from the United States were recruited in 2003-2005. In addition to information on demographics, socio-economic and health status, and clinical/lab results, participants in Renal REGARDS answered questions related to family history of ESRD (defined as a first-degree relative with ESRD); individuals were excluded from the subcohort if they reported current kidney failure and/or dialysis.
| Field | Data |
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| Description of Measure | Family history of ESRD as defined by a first-degree relative (parent, sibling or child) with ESRD |
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| Data Source | REGARDS study, renal sub-population |
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| Type of Data Source | Private |
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| Data Set | Survey, laboratory and biometric results |
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| Health Care System Data | No |
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| Regional or National? | National |
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| Demographic Group | U.S. adults, 45 years of age and older |
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| Numerator | All adults in denominator, by eGFR category |
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| Denominator | U.S. adults, 45 years of age and older, who are not currently on dialysis |
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| Primary Data Source Indicator | Age ≥ 45 years |
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| Primary Indicator Method of Measurement | Survey |
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| U.S. Region Covered by Primary Variable | Continental United States |
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| Secondary (1) Data Source Indicator | Family history of ESRD |
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| Secondary (1) Indicator Method of Measurement | Survey |
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| Secondary (2) Data Source Indicator | eGFR |
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| Secondary (2) Indicator Method of Measurement | Lab-based measurement |
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| Period Currently Available | 2007 |
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| Frequency of Measurement (Primary) | N/A |
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| Pending Data | Unknown |
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| Additional Data Items of Interest | Race/ethnicity, sex, BMI, hypertension (blood pressure and/or medication), diabetes (fasting glucose and/or medication), C-reactive protein (CRP) |
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References and Sources:
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McClellan W, Speckman R, McClure L, Howard V, Campbell RC, Cushman M, Audhya P, Howard G, Warnock DG. Prevalence and Characteristics of a Family History of End Stage Renal Disease among Adults in the United States Population: Reasons for Geographic and Racial Differences in Stroke (REGARDS) Renal Cohort Study. J Am Soc Nephrol 2007;18:1344-1352.