| Description of Measure | Prevalence of self-reported physical activity among U.S. adults, by CKD.
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| Data Set | National Health and Nutrition Examination Survey (NHANES). |
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| Population | Noninstitutionalized US adults aged ≥ 18 years, pregnant women excluded. |
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| Years Included | 2001–March 2020. |
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| Numerator | Adults aged ≥ 18 years who reported being moderately or vigorously active. See below for details. |
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| Denominator | Adults aged ≥ 18 years with serum creatinine, urine albumin, and physical activity measurements. |
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| Definition of CKD | CKD is defined by an estimated glomerular filtration rate (eGFR) <60 ml/min/1.73 m² or albuminuria (urine albumin to creatinine ratio [UACR] ≥30 mg/g). Estimates are based on single estimates of eGFR and UACR. |
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| Estimated Glomerular Filtration Rate (eGFR) | Based on the CKD-EPI (2021) equation for calibrated creatinine: eGFR=142 x [min(serum creatinine in mg/dL) /κ, 1)]**α x [max(serum creatinine/κ, 1)]**-1.20 x 0.9938**age x (1.012 if female).
κ = 0.7 if female and 0.9 if male
α = -0.241 if female and -0.302 if male
** = raise to the power |
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| Albuminuria | Urine albumin to creatinine ratio (UACR) is calculated as urine albumin divided by urine creatinine. Albuminuria is defined as UACR ≥ 30 mg/g. |
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| Serum Creatinine | Serum creatinine values used for eGFR calculation are standardized against isotope dilution mass spectrometry (IDMS). |
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| Urine Albumin | Measured in random urine collection by fluorescent immunoassay. |
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| Physical Activity | Physical activity is defined as self-reporting recreational (sports, fitness, or recreational activities) or work activity (paid work, unpaid work, household chores, or yard work) that causes large (vigorous activity) or small (moderate activity) increases in breathing or heart rate and is done for at least 10 minutes continuously during a typical week. |
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| Age Standardization | Estimates were standardized to the 2010 U.S. Census population for adults. 18–39 years: 37.1%, 40–59 years: 38.1%, 60–69 years: 12.8%, and 70+ years: 12.0%. |
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| Limitations of Indicator | Physical activity, albuminuria, and kidney function are assessed from one-time cross-sectional measurements, possibly overestimating prevalence. |
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| Analytical Considerations | Appropriate NHANES survey weights were used for all analyses; if relative standard error was greater than 30%, the estimates were not shown. Serum creatinine measurements were assay corrected for NHANES years 2005 and 2006 and prior to be combined with later years. |
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