Description of Measure | Neurocognitive performance in children with CKD |
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Data Source | Neurocognitive Assessment and Magnetic Resonance Imaging Analysis of Children and Young Adults with Chronic Kidney Disease (NiCK) Study |
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Type of Data Source | Cross-sectional cohort study |
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Data Set | The Neurocognitive Assessment and Magnetic Resonance Imaging Analysis of Children and Young Adults with Chronic Kidney Disease (NiCK) study is a cross-sectional cohort study involving children and young adults, aged 8 to 25 years from the Philadelphia area |
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Health Care Data System | No |
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Regional or National? | Regional |
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Demographic Group | The Neurocognitive Assessment and Magnetic Resonance Imaging Analysis of Children and Young Adults With Chronic Kidney Disease (NiCK) Study included 90 individuals aged 8 to 25 years with CKD compared with 70 controls; all participants were from the Philadelphia area |
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Numerator | All participants with CKD who underwent 24-hour ambulatory BP monitoring |
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Denominator | All participants who underwent 24-hour ambulatory BP monitoring |
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Definition of CKD | At least 2 estimated glomerular filtration rates (eGFRs)< 90 mL/min/1.73 m2 over at least 6 months; included individuals who were currently or previously on dialysis therapy or had a functioning transplant |
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Glomerular Filtration Rate | Calculated using the bedside CKD in Children (CKiD) equation for individuals aged 8 to 18 years and the 4-variable MDRD (Modification of Diet in Renal Disease) Study equation for those older than 18 years |
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Primary Data Source Indicator | Neurocognitive function |
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Primary Indicator Method of Measurement | A battery of age-specific standardized neurocognitive assessments was performed to assess targeted areas of neurocognition, including executive functioning, attention, memory, and visual spatial processing. All tests were administered by a trained examiner supervised by a licensed psychologist. |
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Secondary Data Source Indicator | eGFR function |
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Secondary Indicator Method of Measurement | eGFR values recorded in medical record |
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Frequency of Measurement | Once |
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Period Currently Available | 2014 |
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Pending Data | None |
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U.S. Region Covered by Primary Variable | Philadelphia area |
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Additional Data Items of Interest | Cause of CKD, income, insurance, age, sex, race, BP |
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Limitations of Indicator | Cross-sectional nature of the study meant that investigators could not assess changes in neurocognitive function that might be linked to changes in kidney function; small sample size |
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Analytical Considerations | As with all cohort studies, selection bias and possible confounding |
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