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Prevalence of CKD Stages 3–5 Among U.S. Adolescents

Prevalence of chronic kidney disease (CKD) stages 3–5 is low among adolescents aged 12–17 years compared to adults, remaining below 1% across all NHANES cycles.

Data Source: NHANES

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Prevalence of CKD Stages 3–5 Among U.S. Adolescents by Overall National Health and Nutrition Examination Survey
2001-2004	2005-2008	2009-2012	2013-2016	2017-2020
.3	.2	.8	.2	.1

CKiD U25 equation used to estimate eGFR in adolescents. Data are not adjusted.

NHANES is a nationally representative, cross-sectional survey that is currently conducted every two years (since 1999) by CDC's National Center for Health Statistics among noninstitutionalized US civilian residents. The survey consists of a standardized in-home interview and a physical examination with blood and urine collected at a mobile examination center.

Data were examined by combining two NHANES cycles to represent four-year periods from 2001 to 2016 and the 2017–March 2020 pre-pandemic cycle.

Field	Data
Description of Measure	Prevalence of CKD among adolescents based on eGFR < 60 ml/min/1.73m².
Data Set	National Health and Nutrition Examination Survey (NHANES).
Population	Noninstitutionalized U.S. adolescents aged 12–17 years.
Years Included	2001–March 2020.
Numerator	Adolescents aged 12–17 years with eGFR <60 ml/min/1.73m².
Denominator	Adolescents aged 12–17 years with serum creatinine measurements.
Definition of CKD	CKD is defined by estimated glomerular filtration rate (eGFR) < 60 ml/min/1.73m².
Estimated glomerular filtration rate (eGFR)	Based on CKiD U25 equation: k(height [cm]/serum creatinine) If male: if age is less than 12 then k=39(1.008*[age_years-12]) if age is 12–17 then k=39(1.045*(age_years-12)) if age is 18–25 then k=50.8 If female: if age is less than 12 then k=36.1(1.008*(age_years-12)) if age is 12–17 then k=36.1(1.023**(age_years-12)) if age is 18–25 then k=41.4
Serum Creatinine	Serum creatinine values used for eGFR calculation are standardized against isotope dilution mass spectrometry (IDMS).
Height	Measured as part of the medical examination.
Limitations of Indicator	Kidney function is assessed from one-time cross-sectional measurement of serum creatinine.
Analytical Considerations	Appropriate NHANES survey weights are used for all analyses; if relative standard error is greater than 30%, the estimates are not shown. Serum creatinine measurements are assay corrected for NHANES years 2005 and 2006 and prior to be combined with later years.