Indicator Details — Solid Organ Transplant Population: Distribution of Risk Factors Among Living Adult Liver Transplant Recipients at 1-Year Post-transplant
Data Sources
 
Stratification and Year Choices:

  Source
  • SRTR

  Chart Format


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There are no differences in distribution of risk factors among living adult liver transplant recipients 1-year post-transplant by CKD status.
Chart Explanation: The x-axis shows the CKD status of adult (age > 21 years) liver transplant recipients at 1-year post-transplant. Categories included are CKD/ESRD or not CKD.
The y-axis shows the percentage of adult liver transplant recipients at 1-year post-transplant that fall within each of the categories listed on the x-axis.
Individuals who received a solid organ transplant in the United States were followed up annually on the anniversary of the transplant date for an assessment of their health status. These data were recorded in the Scientific Registry of Transplant Recipients (SRTR). All analyses presented are limited to adults aged 20 years or older at the time of their first organ transplant. Diabetes status (type 1 or 2) and hypertension status are as listed at the time of transplant. For all transplant recipients, use of calcineurin inhibitors (CNI) to prevent transplant rejection is presented as many of these medications have been shown to be nephrotoxic1. The recording of data in the SRTR pertaining to CKD/kidney function varied by organ type and is discussed below.

Liver transplant data included serum creatinine measurements for each follow-up but do not report whether patients went on dialysis or had a kidney transplant since their last visit. A liver transplant recipient is defined as having CKD or ESRD if he/she has Chronic Kidney Disease Epidemiolgy Collaboration (CKD-EPI) equation estimated GFR <60 ml/min/1.73 m². Donor type (deceased vs. living) information is provided for liver transplant recipients.

1Ojo AO. Renal disease in recipients of nonrenal solid organ transplantation. Semin Nephrol.2007;27(4):498-507. 
FieldData
Description of MeasurePrevalence of CKD (by eGFR) and Renal Dysfunction
Data SourceScientific Registry of Transplant Recipients
Type of Data SourceRegistry
Data SetSRTR
Health Care System DataNo
Regional or National?National
Demographic GroupSolid Organ Transplant Recipients
NumeratorPatients in denominator with eGFR<60 (Liver, Kidney) or ‘renal dysfunction’ (Thoracic) at time of follow-up.
DenominatorPatients with a valid follow-up code who had a first solid organ transplant between 2006 and 2016 and were at least 20 years old at time of transplant.
Definition of diagnosed CKDStage 3, eGFR 30-59 ml/min per 1.73 m² Stage 4, 15-29 ml/min per 1.73 m² Stage 5, <15 ml/min per 1.73 m²
Glomerular filtration rate

Estimated using CKD-EPI formula for calibrated creatinine:
​GFR = 141 × min (Scr /κ, 1)α × max(Scr /κ, 1)-1.209 × 0.993Age × 1.018 [if female] × 1.159 [if black]

Primary Data Source IndicatorSerum Creatinine measurements/Renal Dysfunction indicator
Primary Indicator Method of MeasurementTransplant follow-up
Secondary (1) VariableType of organ transplant
Secondary (1) Variable Method of MeasurementRegistry
Secondary (2) VariableAge
Secondary (2) Variable Method of MeasurementRegistry
Secondary (3) VariableRace/ethnicity
Secondary (3) Variable Method of MeasurementRegistry
Secondary (4) VariableGender
Secondary (4) Variable Method of MeasurementRegistry
Secondary (5) VariableDiabetes
Secondary (5) Variable Method of MeasurementRegistry
Secondary (6) VariableHypertension
Secondary (6) Variable Method of MeasurementRegistry
Secondary (7) VariableCalcineurin Treatment
Secondary (7) Variable Method of MeasurementRegistry
Secondary (8) VariableExpanded Criteria Donor Status
Secondary (8) Variable Method of MeasurementRegistry
Frequency of Measurement (Primary)Multiple measurements per patient
Period Currently Available2007-2017
Pending DataNone.
Additional Data Items of InterestTrends over time, other stratification variables of interest.
Limitations of IndicatorReporting of data across organ types is not consistent. Reporting of kidney function for thoracic recipients may be subjective. Serum creatinine measurements are only taken once per follow-up, probably resulting in a large standard error.
Analytical ConsiderationsMissing data on serum creatinine measurements may be informative.
References and Sources:
Suggested Citation:
Centers for Disease Control and Prevention. Chronic Kidney Disease Surveillance System—United States.
website. http://www.cdc.gov/ckd