Indicator Details: Study Population Distribution of Kidney Function by eGFR
Data Sources
 
Stratification and Year Choices:

  Source
  • Renal REGARDS

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Published literature or one-time analysis, ongoing surveillance not available Published literature or one-time analysis, ongoing surveillance not available

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Odds of a family history of ESRD was 3-4x higher in adults with measured eGFR of 20-29 or 10-19 ml/min/1.73m² as compared to adults with an eGFR > 60 ml/min/1.73m².

Individuals of black race, females, the obese and those with diabetes or increased serum C-reactive protein (CRP; a measure of inflammation) concentrations were significantly more likely to report a family history of ESRD.
Chart Explanation: Adults within the lowest eGFR categories were significantly more likely to report a family history of ESRD. Multivariable analyses indicated that individuals of black race, females, the obese, and those with diabetes or increased serum C-reactive protein (CRP; a measure of inflammation) concentrations were significantly more likely to report a family history of ESRD.
Renal REGARDS represents a subcohort of 12,030 participants from the Reasons for Geographical and Racial Difference in Stroke (REGARDS) cohort study who. Participants are a population-based sample of adults, 45 years and older, from the United States were recruited in 2003-2005. In addition to information on demographics, socio-economic and health status, and clinical/lab results, participants in Renal REGARDS answered questions related to family history of ESRD (defined as a first-degree relative with ESRD); individuals were excluded from the subcohort if they reported current kidney failure and/or dialysis.
FieldData
Description of MeasureFamily history of ESRD as defined by a first-degree relative (parent, sibling or child) with ESRD
Data SourceREGARDS study, renal sub-population
Type of Data SourcePrivate
Data SetSurvey, laboratory and biometric results
Health Care System DataNo
Regional or National?National
Demographic GroupU.S. adults, 45 years of age and older
NumeratorAll adults in denominator, by eGFR category
DenominatorU.S. adults, 45 years of age and older, who are not currently on dialysis
Primary Data Source IndicatorAge ≥ 45 years
Primary Indicator Method of MeasurementSurvey
U.S. Region Covered by Primary VariableContinental United States
Secondary (1) Data Source IndicatorFamily history of ESRD
Secondary (1) Indicator Method of MeasurementSurvey
Secondary (2) Data Source IndicatoreGFR
Secondary (2) Indicator Method of MeasurementLab-based measurement
Period Currently Available2007
Frequency of Measurement (Primary)N/A
Pending DataUnknown
Additional Data Items of InterestRace/ethnicity, sex, BMI, hypertension (blood pressure and/or medication), diabetes (fasting glucose and/or medication), C-reactive protein (CRP)
References and Sources:
  • McClellan W, Speckman R, McClure L, Howard V, Campbell RC, Cushman M, Audhya P, Howard G, Warnock DG. Prevalence and Characteristics of a Family History of End Stage Renal Disease among Adults in the United States Population: Reasons for Geographic and Racial Differences in Stroke (REGARDS) Renal Cohort Study. J Am Soc Nephrol 2007;18:1344-1352.
Suggested Citation:
Centers for Disease Control and Prevention. Chronic Kidney Disease Surveillance System—United States.
website. http://www.cdc.gov/ckd