The overall prevalence of liver cysts among the ADPKD patients is high (83%)
Liver cysts are more common in older ADPKD patients (ages 35-46; 94%) than in younger ADPKD patients (ages 15-24; 58%)
Prevalence did not differ by gender
Chart Explanation: There was a considerable progression of renal cyst growth and renal enlargement among the participants of the CRISP cohort before the loss of kidney function. The overall prevalence of liver cystic disease among the CRISP participants was higher (almost 83%). Among patients between 15-24 years, 25-34 years, and 35-46 years of age, the prevalence was 58%, 85%, and 94% respectively.
The Consortium for Radiologic Imaging Studies of Polycystic Kidney Disease (CRISP) is a 10-year prospective cohort study that started in March 1999 and was created to develop innovative imaging techniques and analyses using magnetic resonance (MR) imaging to reliably and accurately measure cyst and renal volume in ADPKD individuals early in the course of their disease. The purpose of this study was to determine if (1) renal or cyst volume can be measured reliably and accurately; (2) change in renal or cyst volume can be detected over a relatively short period of time; and (3) an increase in cyst or renal volume is associated with loss of renal function in ADPKD. The primary overall goal of CRISP was to develop imaging methods to follow disease progression and to evaluate treatments for ADPKD.
Autosomal dominant polycystic kidney disease (ADPKD) is the most commonly inherited genetic renal disease and cause of kidney failure in adults and children. It is characterized by the growth of numerous cysts in the kidneys and often culminates in end-stage renal disease. CRISP was created to develop methods that reliably measure the progression of cyst and renal growth before loss of kidney function among individuals with ADPKD. A total of 230 ADPKD patients between 15 and 46 years old and with a creatinine clearance of >70 ml/min were recruited for CRISP I. Enrolled subjects were evaluated at baseline (magnetic resonance imaging, clinical evaluation) and for 3 years thereafter. Two years after the completion of CRISP I, participants were contacted again to schedule for a baseline evaluation for CRISP II (year 6). 203 participants were enrolled for CRISP II. Complete methods can be found in Bae et al. (2006)
| Field | Data |
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| Description of Measure | Prevalence of hepatic cysts among patients with autosomal dominant polycystic kidney disease (ADPKD)
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| Data Source | Consortium for Radiologic Imaging Studies of Polycystic Kidney Disease (CRISP) study
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| Type of Data Source | Private
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| Data Set | CRISP summarized data
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| Health Care System Data | No
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| Regional or National? | National
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| Demographic Group | ADPKD patients in the CRISP study with relatively intact initial renal function
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| Numerator | Participants with ADPKD recruited with hepatic cysts
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| Denominator | Enrolled CRISP participants with ADPKD with meagnetic resonance imaging and clinical evaluation data
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| Definition of CKD | Cockcroft-Gault estimate of creatine clearence >70mL/min
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| Primary Data Source Indicator | Presence of hepatic cysts
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| Primary Indicator Method of Measurement | High-resolution magnetic resonance imaging
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| Frequency of Measurement (Primary) | Once. Baseline
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| Secondary (1) Data Source Indicator | Age
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| Secondary (1) Indicator Frequency of Measurement | Once; baseline visit
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| Secondary (2) Data Source Indicator | Gender
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| Secondary (2) Indicator Frequency of Measurement | Once; baseline visit
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| U.S. Region Covered by Primary Variable | Mayo Foundation (Rochester, MN), University of Alabama (Brimingham, AL), Emory University (Atlanta, GA), University of Kansas Medical Center (Kansas City, KS)
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| Period Currently Available | 2001–2007 |
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| Additional Data Items of Interest | None
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| Limitations of Indicator | Hepatic cysts measured only after first year of data collection
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| Analytical Considerations | Data summarized by CRISP investigators (see Bae et al. as with all cohort studies, selection bias and possible confounding
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References and Sources:
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Bae KT, Zhu F, Chapman AB, et al. Magnetic resonance imaging evaluation of hepatic cysts in early autosomal-dominant polycystic kidney disease: the Consortium for Radiologic Imaging Studies of Polycystic Kidney Disease cohort. Clin J Am Soc Nephrol. 2006;1(1):64-9.