Odds of a family history of ESRD was 3-4x higher in adults with measured eGFR of 20-29 or 10-19 ml/min/1.73m² as compared to adults with an eGFR > 60 ml/min/1.73m².
Individuals of black race, females, the obese and those with diabetes or increased serum C-reactive protein (CRP; a measure of inflammation) concentrations were significantly more likely to report a family history of ESRD.
Chart Explanation: Adults within the lowest eGFR categories were significantly more likely to report a family history of ESRD. Multivariable analyses indicated that individuals of black race, females, the obese, and those with diabetes or increased serum C-reactive protein (CRP; a measure of inflammation) concentrations were significantly more likely to report a family history of ESRD.
Renal REGARDS represents a subcohort of 12,030 participants from the Reasons for Geographical and Racial Difference in Stroke (REGARDS) cohort study who. Participants are a population-based sample of adults, 45 years and older, from the United States were recruited in 2003-2005. In addition to information on demographics, socio-economic and health status, and clinical/lab results, participants in Renal REGARDS answered questions related to family history of ESRD (defined as a first-degree relative with ESRD); individuals were excluded from the subcohort if they reported current kidney failure and/or dialysis.
|Description of Measure||Family history of ESRD as defined by a first-degree relative (parent, sibling or child) with ESRD|
|Data Source||REGARDS study, renal sub-population|
|Type of Data Source||Private|
|Data Set||Survey, laboratory and biometric results|
|Health Care System Data||No|
|Regional or National?||National|
|Demographic Group||U.S. adults, 45 years of age and older|
|Numerator||All adults in denominator, by eGFR category|
|Denominator||U.S. adults, 45 years of age and older, who are not currently on dialysis|
|Primary Data Source Indicator||Age ≥ 45 years|
|Primary Indicator Method of Measurement||Survey|
|U.S. Region Covered by Primary Variable||Continental United States|
|Secondary (1) Data Source Indicator||Family history of ESRD|
|Secondary (1) Indicator Method of Measurement||Survey|
|Secondary (2) Data Source Indicator||eGFR|
|Secondary (2) Indicator Method of Measurement||Lab-based measurement|
|Period Currently Available||2007|
|Frequency of Measurement (Primary)||N/A|
|Additional Data Items of Interest||Race/ethnicity, sex, BMI, hypertension (blood pressure and/or medication), diabetes (fasting glucose and/or medication), C-reactive protein (CRP)|
References and Sources:
McClellan W, Speckman R, McClure L, Howard V, Campbell RC, Cushman M, Audhya P, Howard G, Warnock DG. Prevalence and Characteristics of a Family History of End Stage Renal Disease among Adults in the United States Population: Reasons for Geographic and Racial Differences in Stroke (REGARDS) Renal Cohort Study. J Am Soc Nephrol 2007;18:1344-1352.